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University of Illinois at Chicago
Seeking highly motivated individuals to work in the area of cellular signaling related to cancer development and progression. Research in the laboratory is focused on two major areas: 1. RAS GTPase signaling and transformation; and 2. Compartmentalized signaling by the intersectin (ITSN) scaffold protein.

We have identified a novel allosteric regulatory site in RAS that is involved in the dimerization and nanoclustering of RAS at the plasma membrane (Spencer-Smith et. al. Nat. Chem. Biol, 2016 doi: 10.1038/nchembio.2231). Targeting this site blocks oncogenic RAS-mediated signaling and transformation by inhibiting RAS-induced dimerization and activation of the RAF kinase. Current studies are examining the role of RAS dimerization/nanoclustering in additional RAS effector pathways as well as using novel affinity reagents to probe isoform-specific differences in RAS signaling.

ITSN is a multi-domain scaffold protein involved in regulating endocytosis and cellular signaling (Herrero-Garcia and O’Bryan, Biochimica et Biophysica Acta, 1864, 2017, 23–30). However, overexpression of ITSN has been implicated in a number of human malignancies including neuroblastoma. Current projects center on ITSN’s role in regulating RAS family GTPases, lipid kinases, ubiquitin ligases, protein trafficking pathways, and the importance of these ITSN-regulated pathways in human disease, particularly cancer.

Chicago is the third largest metropolitan area in the US with a highly diverse population. The University of Illinois at Chicago is part of a thriving and interactive biomedical community that includes the University of Chicago, Northwestern University, Loyola University, and Rush University. In addition, Chicago offers an array of entertainment possibilities including world-class museums, dance, theater, a vibrant music scene, several professional sports teams, and numerous outdoor activities.
Candidates must have experience in molecular biology, biochemistry, and cell biology. In addition, candidates must have a Ph.D., M.D. or combined M.D.-Ph.D. degrees and must be eligible for employment in the U.S. These are non tenure-track positions, with renewal dependent on continued funding. Start date is negotiable although preference will be given to candidates that can begin immediately. Salary range is commensurate with experience for Postdoc. Position is a benefit eligible position.
2/28/2017 11:54:02 AM

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