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I was an extremely happy lab rat—I loved being at the bench. I would stay awake at night thinking of the questions that most interested me and dreaming up experiments that would address them. I had a good publication record and landed a post-doc in a top laboratory that I hoped would help me launch a successful academic career. In the summer of my fourth year as a post-doc, I presented my research at an international meeting. I was delighted when scientists at other universities expressed interest in my work—a few even approached me to see whether I’d be going on the job market soon. They knew of positions that were opening up, and suggested I consider giving job talks in the fall. I flew back home ...